HCID 22860484, 화합물 → Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-

HRID 433108노트

반응식

HRID 433108 반응식
C([O:5][C:6](=[O:14])[C@H:7]([CH3:13])[CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])(C)(C)C>Cl.O1CCOCC1>[CH3:13][C@H:7]([CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])[C:6]([OH:14])=[O:5]

참가 물질

3

반응물 1

HCID 22860484HCID 22860484, 화합물

생성물 1

HCID 15814191Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-수율 71.9%

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

To 2.68 g of 2(S)-methyl-3-(methylsulfonyl)-propionic acid t-butyl ester was added 20 mL of 4N hydrochloric acid/dioxane and the mixture stirred at room temperature for 19 hours. The solvent was removed under reduced pressure to afford 2.18 g of crude product, which was recrystallized from ethyl acetate/hexane to yield 1.44 g of 2(S)-methyl-3-(methylsulfonyl)propionic acid as white crystals.

후처리

  1. customThe solvent was removed under reduced pressure
  2. customto afford 2.18 g of crude product, which
  3. customwas recrystallized from ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-fb954df811dc4feb8bdcc3b8cfcb3956
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667307B2

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