Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citric Acid → Formoterol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Trisodium citrate | HCID 6224 | — |
| 반응물 | (E)-but-2-enedioic acid N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide dihydrate | HCID 11954385 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Formoterol | HCID 3410 | — |
반응 단계
To a 5 L stainless steel vessel were added 0.68 g citric acid USP, 1.99 g sodium citrate USP, and 17.5 g sodium chloride USP. Purified water USP (2 L) was added to the stainless steel vessel and the contents were mixed with an overhead stirrer at a speed of 240 rpm for 10 minutes. Formoterol fumarate dihydrate (0.17 g for low dosage strength formulation, 0.34 g for high dosage strength formulation) was added and the solution was stirred at 240 rpm for 90 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06667344B2 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-6317a0f1cf7b47ee8cb8e7e5955d3cb5 |
| 출처 메모 | uspto-grants-2003_12 |