Pyridine → N-(2-Chloro-4-fluorosulphonylphenyl)-2-acetoxy-2-methylpropanamide

HRID 433331노트

반응식

HRID 433331 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([S:9]([F:12])(=[O:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:13]([O:16][C:17]([CH3:22])([CH3:21])[C:18](Cl)=[O:19])(=[O:15])[CH3:14].N1C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[CH:8]=[C:7]([S:9]([F:12])(=[O:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:18](=[O:19])[C:17]([O:16][C:13](=[O:15])[CH3:14])([CH3:22])[CH3:21]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 1234962-Acetoxyisobutyroyl chlorideHCID 2827514-Amino-3-chlorobenzenesulfonyl fluoride

생성물 1

HCID 18758703N-(2-Chloro-4-fluorosulphonylphenyl)-2-acetoxy-2-methylpropanamide수율 49.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2-chloro-4-fluorosulphonylaniline (2.5 g, 12 mmol), 2-acetoxyisobutyryl chloride (2.35 g, 14 mmol) and pyridine (1.2 ml, 14.5 mmol), in DCM (50 ml) was stirred at ambient temperature for 18 h. The mixture was washed with water, dried and evaporated to dryness. The residue was purified by column chromatography using 25% EtOAc/isohexane and the oily product, the title compound (2.0 g, 5.9 mmol), solidified on standing. MS: 336.

후처리

  1. washThe mixture was washed with water
  2. customdried
  3. customevaporated to dryness
  4. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-4be0baf51a11426498c953b2f9f7af64
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667342B1

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