Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromobenzaldehyde → Phenylmethyl (2S)-4-[(4-bromophenyl)methyl]-2-methyl-1-piperazine Carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromobenzaldehyde | HCID 70741 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | Benzyl (2S)-2-methylpiperazine-1-carboxylate | HCID 40425199 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | Phenylmethyl (2S)-4-[(4-bromophenyl)methyl]-2-methyl-1-piperazine Carboxylate | HCID 25224210 | 84.2% |
반응 단계
A mixture of 4-bromobenzaldehyde (1.19 g, 6.42 mmol), phenylmethyl (2S)-2-methyl-1-piperazinecarboxylate (1.505 g, 6.42 mmol) and sodium triacetoxyborohydride (2.04 g, 9.63 mmol) in 1,2-DCE (15 ml) was stirred at room temperature overnight. Saturated aq. NaHCO3 solution was added and the mixture stirred for 30 mins. Product was extracted and the extracts dried (Na2SO4). Chromatography (0-30% EtOAc in pentane) gave the title compound (2.18 g). MS (ES): MH+ 403/405.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536182B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-d3f1cc6cc426466f9662703f3e0ae627 |
| 출처 메모 | uspto-grants-2013_09 |