Chlorotrimethylsilane → Methyl 2-(4-(bromomethyl)phenyl)acetate

HRID 43347

반응식

HRID 43347 반응식
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:13][Si](Cl)(C)C>CO>[Br:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 6397ChlorotrimethylsilaneHCID 45190564-(Bromomethyl)phenylacetic acid

생성물 1

HCID 11770640Methyl 2-(4-(bromomethyl)phenyl)acetate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4-(bromomethyl)phenylacetic acid (20 g, 87.3 mmol) in MeOH (200 ml) was added trimethylsilylchloride (2 ml) and the reaction stirred for 2 h. The solvent was removed in vacuo and the residue was twice re-dissolved in MeOH (200 ml) and re-concentrated to give the title compound (21.08 g). δH (CDCl3, 250 MHz) 7.36 (2H, d), 7.26 (2H, d), 4.49 (2H, s), 3.69 (3H, s), 3.62 (2H, s).

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was twice re-dissolved in MeOH (200 ml)
  3. concentrationre-concentrated

출처 및 근거

ORD 기록
ord-b6f12120b68f4cc6a572fb91af9e6f91
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536182B2

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