Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl pyruvate → N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl pyruvate | HCID 11748 | — |
| 반응물 | 1,3-Benzodioxol-5-amine | HCID 84310 | — |
| 반응물 | N-(3,4-methylenedioxyphenyl)alanine methyl ester | HCID 54531586 | — |
| 용매 | Isobutanol | HCID 6560 | — |
| 생성물 | N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester | HCID 54134455 | — |
반응 단계
Following reductive amination General Procedure AA above and using 3,4-methylenedioxyaniline (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-methylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above and using iso-butanol to provide the title compound as an oil. The reaction was monitored by silica gel tlc (Rf=0.61 in 25% EtOAc/hexanes). Purification was by preparative plate chromatography with silica gel using 25% EtOAc/hexanes as the eluant.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06667305B1 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-54ae923696ed4c0abb346d737c0f3283 |
| 출처 메모 | uspto-grants-2003_12 |