2,5-Difluorophenylacetic acid → N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

HRID 433539노트

반응식

HRID 433539 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[F:1])[CH:14]([CH3:16])[CH3:15]

참가 물질

3

반응물 2

HCID 5228232,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

생성물 1

HCID 22894969N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

실험 절차

Following General Procedure BI above, and using 2,5-difluorophenylacetic acid (Aldrich) and alanine iso-Butyl Ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

후처리

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

출처 및 근거

ORD 기록
ord-93cde7f179944c3b876abdebab23badc
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667305B1

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