Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluoroaniline → tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluoroaniline | HCID 9742 | — |
| 반응물 | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Isopropyl Acetate | HCID 7915 | — |
| 생성물 | tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate | HCID 23137591 | — |
반응 단계
Sodium triacetoxyborohydride (NaBH(OAc)3 74 g, 0.35 mol) was added to a stirred solution of 1,1-Dimethylethyl 4-oxo-1-piperidinecarboxylate (50 g, 0.25 mol) and 3-Fluoroaniline (24 ml, 0.25 mol) in isopropyl acetate (1-PrOAc, 500 ml) and the slurry stirred overnight.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536182B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-37cc2d7a1d7c499ab3bcccd0f2ba04eb |
| 출처 메모 | uspto-grants-2013_09 |