Diisobutylaluminumhydride → HCID 23445089, 화합물

반응식

C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][N:12]=2)[CH:10]=1)=O)C.[H-].C([Al+]CC(C)C)C(C)C>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([N:9]2[CH:10]=[C:6]([CH2:4][OH:3])[N:7]=[CH:8]2)=[N:12][CH:13]=1

참가 물질

반응물 2

HCID 21225700Diisobutylaluminumhydride

HCID 537529911-(5-Chloro-pyridin-2-yl)-1H-imidazole-4-carboxylic Acid Ethyl Ester

생성물 1

HCID 23445089HCID 23445089, 화합물

실험 절차

Following the general method described in example 388, 1-(5-chloro-pyridin-2-yl)-1H-imidazole-4-carboxylic acid ethyl ester was reacted with diisobutylaluminum hydride. After hydrolytic workup and chromatography the title compound was obtained as a light brown crystalline solid. Mp. 82-87° C. (AcOEt/Et2O), MS: m/e=210 (M+H+).

출처 및 근거

ORD 기록: ord-bde480d7c53e418bb93d8442670beaa7
출처 데이터셋: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06667335B2

반응 노트

불러오는 중…