Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → Dichloromethane methanol ammonium hydroxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Ethyl oxoacetate | HCID 70211 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-1,3-propanediamine | HCID 22488891 | — |
| 생성물 | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| 생성물 | 2-[[3-[(1,3-Benzodioxol-5-ylmethyl)amino]propyl]amino]acetic acid ethyl ester | HCID 69742407 | — |
반응 단계
To N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-1,3-propanediamine (33 g, 0.15 mol) in CH2Cl2 (500 mL) was added ethyl glyoxalate (30 mL of a 50% toluene solution, 0.15 mol) and sodium triacetoxyborohydride (40 g, 0.19 mol). After stirring for 4 hours, the reaction was washed with aqueous potassium carbonate and the solvent removed in vacuo. Chromatography on silica with CH2Cl2/MeOH/ammonium hydroxide gave 14 g of 2-([3-[(1,3-benzodioxol-5-ylmethyl)amino]propyl]amino]acetic acid, ethyl ester, a compound of formula (Y10)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06670473B2 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-55108abb899d4b6da727c78b3e27185b |
| 출처 메모 | uspto-grants-2003_12 |