Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → [1-((S)-2-amino-3-hydroxy-propyl)-piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | (S)-4-[4-(4-chloro-benzoyl)-piperidin-1-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester | HCID 68809159 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | [1-((S)-2-amino-3-hydroxy-propyl)-piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride | HCID 68809448 | — |
반응 단계
(S)-4-[4-(4-chloro-benzoyl)-piperidin-1-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (0.68 g, 1.55 mmol) is added to a solution of hydrogen chloride in ethanol (5 ml, 5.5M). The reaction mixture is stirred at ambient temperature for 1 hour, then evaporated to dryness to afford [1-((S)-2-amino-3-hydroxy-propyl)-piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride. [MH] 297.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06670379B2 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-713c0094f74b43459937b20cdfdf2805 |
| 출처 메모 | uspto-grants-2003_12 |