Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Fluorotoluene → 4-Fluorobenzyl bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Fluorotoluene | HCID 9603 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 촉매 | Benzoyl Peroxide | HCID 7187 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 4-Fluorobenzyl bromide | HCID 68021 | 101.1% |
반응 단계
A 300-ml flask was charged with 16.6 g of 4-fluorotoluene, 30.0 g of NBS, 0.5 g of benzoyl peroxide and 150 ml of carbon tetrachloride, and the mixture was refluxed for 2.0 hours. The reaction mixture was cooled to room temperature, and the formed precipitate was removed by filtration and the residual CCl4 solution was washed with dilute alkali and then with water, dried over Na2SO4, and evaporated under reduced pressure to give 28.8 g of crude 4-fluorobenzyl bromide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04397864 |
| 출처 데이터셋 | uspto-grants-1983_08 |
| ORD ID | ord-488f31c16d854192accd904c27116779 |
| 출처 메모 | uspto-grants-1983_08 |