Aniline → Butanamide, 4-chloro-3-oxo-N-phenyl-

HRID 434559노트

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HRID 434559 반응식
Cl[C:2]1([CH2:7][Cl:8])[O:5][C:4](=[O:6])[CH2:3]1.[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(Cl)Cl.C(=O)(O)[O-].[Na+]>[Cl:8][CH2:7][C:2](=[O:5])[CH2:3][C:4]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:6]

참가 물질

5

반응물 2

HCID 6115AnilineHCID 137182814-Chloro-4-(chloromethyl)oxetan-2-one

생성물 1

HCID 38215Butanamide, 4-chloro-3-oxo-N-phenyl-

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 516892Sodium Bicarbonate용매

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온도
0 °C

실험 절차

7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 150 parts of methylenechloride containing 4.2 parts of anhydrous sodium bicarbonate and the solution is cooled to 0° C. 4.7 Parts of aniline are then added over 30 minutes and the reaction mixture is finally stirred for 48 hours at room temperature. The solids are then filtered off and the filtrate evaporated. The residue is crystallised twice from chloroform to give γ-chloroacetoacetanilide, m.p. 142°-143° C.

후처리

  1. filtrationThe solids are then filtered off
  2. customthe filtrate evaporated
  3. customThe residue is crystallised twice from chloroform

출처 및 근거

ORD 기록
ord-1de118cf597a444a877d081882727599
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04398033

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