N,O-Dimethylhydroxylamine → N'-[4-(2-naphthyloxy)phenyl]-N-methoxy-N-methylurea

HRID 434606노트

반응식

HRID 434606 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]=[C:19]=[O:20])=[CH:14][CH:13]=1.[CH3:21][NH:22][O:23][CH3:24]>C1C=CC=CC=1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:20])[N:22]([O:23][CH3:24])[CH3:21])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 14232N,O-DimethylhydroxylamineHCID 127740664-(2-Naphthyloxy)phenyl isocyanate

생성물 1

HCID 12893343N'-[4-(2-naphthyloxy)phenyl]-N-methoxy-N-methylurea수율 87.3%

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

Thirteen grams of 4-(2-naphthyloxy)phenyl isocyanate were dissolved in 100 ml of benzene, and a solution of 4 g of N,O-dimethylhydroxylamine in 50 ml of benzene was added dropwise thereto at a temperature below 30° C. The reaction mixture was allowed to stand at room temperature for 30 minutes, and the solvent was then removed under reduced pressure. The residue was recrystallized from ethanol to obtain 14 g of N'-[4-(2-naphthyloxy)phenyl]-N-methoxy-N-methylurea as white needles. M.P., 102°-103° C.

후처리

  1. customat a temperature below 30° C
  2. customthe solvent was then removed under reduced pressure
  3. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-741eeb4685144689974d366f36c05c77
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04399072

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