Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole → 2-Methyl-4-morpholino-5-fluoro-7-bromoindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole | HCID 20258982 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-Methyl-4-morpholino-5-fluoro-7-bromoindole | HCID 20258993 | 65.3% |
반응 단계
Raney nickel (400 g) was added to a solution of 58 g of 2-methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole in 1 l of dioxane and the mixture was allowed to react at room temperature for 4 hours. After completion of the reaction Raney nickel was removed by filtration, and the filtrate was concentrated under reduced pressure. 33 g of 2-methyl-4-morpholino-5-fluoro-7-bromoindole was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04399134 |
| 출처 데이터셋 | uspto-grants-1983_08 |
| ORD ID | ord-bdc221d26d4a49d99d105f77bbed8a1c |
| 출처 메모 | uspto-grants-1983_08 |