p-Toluenesulfonic acid → 3-Ethyl-3-methyl-1-(3-nitrophenyl)pyrrolidine-2,5-dione

HRID 435046

반응식

HRID 435046 반응식
[CH3:1][C:2]([CH2:10][CH3:11])([CH2:6][C:7]([OH:9])=O)[C:3]([OH:5])=O.[N+:12]([C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18])([O-:14])=[O:13].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C(C)=CC=CC=1>[N+:12]([C:15]1[CH:16]=[C:17]([N:18]2[C:7](=[O:9])[CH2:6][C:2]([CH3:1])([CH2:10][CH3:11])[C:3]2=[O:5])[CH:19]=[CH:20][CH:21]=1)([O-:14])=[O:13]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 74233-NitroanilineHCID 977762-Ethyl-2-methylsuccinic acid

생성물 1

HCID 131892323-Ethyl-3-methyl-1-(3-nitrophenyl)pyrrolidine-2,5-dione

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

Sixty-four g. of 2-methyl-2-ethylsuccinic acid was combined with 55.2 g. of m-nitro aniline in 250 ml. of xylene. One-half g. of p-toluene sulfonic acid was added and the mixture heated to reflux under a modified Dean Stark apparatus. After 15-16 ml. of water was removed, the mixture was cooled and the product recovered by filtration. Yield was 78 g. of a product having a m.p. of 88°-89° C. The product was identified as the title compound by analysis of infrared spectra.

후처리

  1. temperaturethe mixture heated
  2. temperatureto reflux under a modified Dean Stark apparatus
  3. customof water was removed
  4. temperaturethe mixture was cooled
  5. filtrationthe product recovered by filtration

출처 및 근거

ORD 기록
ord-54daf09e55dd413da76b36ceb4897951
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04400202

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