1,4-Dichlorobenzene → 4-Methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione

반응식

[C:1](Cl)(=[O:5])[C:2](Cl)=[O:3].[CH:7]1C(Cl)=CC=C(Cl)C=1.[NH2:15][C:16]1[C:21]([NH:22]C)=[CH:20][CH:19]=[CH:18][N:17]=1>>[CH3:7][N:15]1[C:2](=[O:3])[C:1](=[O:5])[NH:22][C:21]2[CH:20]=[CH:19][CH:18]=[N:17][C:16]1=2

참가 물질

반응물 3

HCID 46851,4-Dichlorobenzene

HCID 65578Oxalyl chloride

HCID 122384043-N-methylpyridine-2,3-diamine

생성물 1

HCID 131929424-Methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione

실험 절차

To a mixture of 8 ml. of oxalyl chloride in 150 ml. dichlorobenzene at 60° C. was added lowly 7.5 g. of 2-amino-3-methylaminopyridine. After completion of addition, the temperature of the reaction mixture was allowed to rise to 130° C. It was stirred at this temperature for 1 hour, filtered hot, and the solid washed with ether, m.p. 168°-174° C.