3,5-Dimethoxybenzaldehyde → 3,5-Dimethoxy-beta-methylstyrene oxide

HRID 435138

반응식

HRID 435138 반응식
[C:1]1([SH+]C2C=CC=CC=2)C=CC=C[CH:2]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:21]=[C:22]([O:24][CH3:25])[CH:23]=1)[CH:19]=[O:20]>O1CCCC1>[CH3:25][O:24][C:22]1[CH:21]=[C:18]([CH:17]=[C:16]([O:15][CH3:14])[CH:23]=1)[CH:19]1[O:20][CH:1]1[CH3:2]

참가 물질

4

반응물 2

HCID 817473,5-DimethoxybenzaldehydeHCID 22290449Diphenylsulfonium

생성물 1

HCID 130604403,5-Dimethoxy-beta-methylstyrene oxide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
-78 °C

실험 절차

To a -78° C. solution of diphenylsulfonium ethylide (1.0 mole) in tetrahydrofuran (one liter) is slowly added 3,5-dimethoxybenzaldehyde (1.0 mole). The reaction mixture is stirred at -78° C. for 3 hours and then allowed to warm to room temperature. It is then added to ether-water and the ether phase separated. The ether phase is washed with water, dried (MgSO4) and evaporated. Fractional distillation of the residue gives the title product.

후처리

  1. customTo a -78° C.
  2. temperatureto warm to room temperature
  3. customthe ether phase separated
  4. washThe ether phase is washed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. distillationFractional distillation of the residue

출처 및 근거

ORD 기록
ord-dd3db32d38dd4e279968a1d7d520def0
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04400385

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