Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 4-chloroacetoacetate → Ethyl cis(+/-)-[2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-thiazol-4-yl]acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 4-chloroacetoacetate | HCID 69484 | — |
| 반응물 | Benzyl cis(+/-)-(1-carbamothioyl-3-methoxypiperidin-4-yl)-carbamate | HCID 86648521 | — |
| 생성물 | Ethyl cis(+/-)-[2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-thiazol-4-yl]acetate | HCID 86648522 | 96.4% |
반응 단계
The same operation as in Example (22b) was performed using benzyl cis(±)-(1-carbamothioyl-3-methoxypiperidin-4-yl)-carbamate obtained in Example (64b) (97 mg, 0.30 mmol) and ethyl 4-chloro-acetoacetate (60 μL, 0.44 mmol), to obtain 125.4 mg of the title compound as a colorless oily substance (96%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536197B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-93109e34f8a2498c9af758f82f8ac60e |
| 출처 메모 | uspto-grants-2013_09 |