Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 1-(4-Carbomethoxy-2-methylbutanoyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl 1,2,3,4-tetrahydroquinoline-2-carboxylate | HCID 2736972 | — |
| 반응물 | Methyl 5-chloro-4-methyl-5-oxopentanoate | HCID 13192898 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(4-Carbomethoxy-2-methylbutanoyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester | HCID 13192899 | — |
반응 단계
The mixture of 1.0 g of 1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester (Ber. 61,2377), 0.87 g of 4-carbomethoxy-2-methylbutanoyl chloride, 1.44 g of powdered potassium carbonate and 20 ml of methylene chloride is stirred at room temperature overnight. It is cooled with ice, and 50 ml of water are added. The organic layer is separated, washed with N-hydrochloric acid and water, dried and evaporated, to yield the 1-(4-carbomethoxy-2-methylbutanoyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester, showing NMR-peaks at 0.85, 1.25, 3.35, 3.65 and 3.75 ppm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04401818 |
| 출처 데이터셋 | uspto-grants-1983_08 |
| ORD ID | ord-624f9efadedf425586d828304aa9291a |
| 출처 메모 | uspto-grants-1983_08 |