Dicyclohexylcarbodiimide → Thyroxine

HRID 435514

반응식

HRID 435514 반응식
C(O[NH:6][C@H:7]([C:27]([OH:29])=[O:28])[CH2:8][C:9]1[CH:16]=[C:14]([I:15])[C:13]([O:17][C:18]2[CH:25]=[C:23]([I:24])[C:22]([OH:26])=[C:20]([I:21])[CH:19]=2)=[C:11]([I:12])[CH:10]=1)(C)(C)C.ON1C(=O)CCC1=O.C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C=O>[NH2:6][C@H:7]([C:27]([OH:29])=[O:28])[CH2:8][C:9]1[CH:10]=[C:11]([I:12])[C:13]([O:17][C:18]2[CH:19]=[C:20]([I:21])[C:22]([OH:26])=[C:23]([I:24])[CH:25]=2)=[C:14]([I:15])[CH:16]=1

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 80170N-HydroxysuccinimideHCID 54358334HCID 54358334, 화합물

생성물 1

HCID 5819Thyroxine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1.23 g (1.4 mmoles) of N-(tert-butoxy)-L-thyroxine and 0.16 g (1.4 mmoles) of N-hydroxysuccinimide are dissolved in 20 mL dimethylformamide. 0.31 g (1.5 mmoles) of dicyclohexyl carbodiimide is added to the solution which is then stirred at room temperature for 18 h. The urea precipitated during the reaction is removed by filtration and the filtrate, containing the active ester, is stored at -20° C.

후처리

  1. customThe urea precipitated during the reaction
  2. customis removed by filtration
  3. additionthe filtrate, containing the active ester
  4. customis stored at -20° C.

출처 및 근거

ORD 기록
ord-766db094727d4f78be203c00f89a3ea5
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04401765

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