Potassium Cyanide → 3-Methyl-6-(phenylthio)-phenylacetonitrile

HRID 435608노트

반응식

HRID 435608 반응식
[C-:1]#[N:2].[K+].[CH3:4][C:5]1[CH:6]=[C:7]([C:10]([S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][CH:12]=1)[CH2:8]Cl>O.C(O)C>[CH3:4][C:5]1[CH:6]=[C:7]([CH2:8][C:1]#[N:2])[C:10]([S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][CH:12]=1

참가 물질

5

반응물 2

HCID 9032Potassium CyanideHCID 125391003-Methyl-6-(phenylthio)-benzyl chloride

생성물 1

HCID 125391013-Methyl-6-(phenylthio)-phenylacetonitrile

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

570.7 g of 3-methyl-6-(phenylthio)-benzyl alcohol are dissolved in 1.5 litres of benzene and heated under reflux. There are added dropwise thereto within 45 minutes 352 ml of thionyl chloride and the mixture is boiled for a further 90 minutes. Then the mixture is concentrated under reduced pressure and there is obtained 3-methyl-6-(phenylthio)-benzyl chloride as a red-brown oil. 194 g of potassium cyanide in 250 ml of water are heated under reflux for 17 hours under an argon atmosphere with 616.9 g of 3-methyl-6-(phenylthio)-benzyl chloride in 900 ml of ethanol. Then the ethanol is distilled off under reduced pressure, the residue then diluted with water and extracted with ether. The extracts are washed with water, dried over sodium sulphate and evaporated. There is obtained 3-methyl-6-(phenylthio)-phenylacetonitrile as an oil.

후처리

  1. distillationThen the ethanol is distilled off under reduced pressure
  2. additionthe residue then diluted with water
  3. extractionextracted with ether
  4. washThe extracts are washed with water
  5. dry with materialdried over sodium sulphate
  6. customevaporated

출처 및 근거

ORD 기록
ord-2b0640db142e4479a44076773d148632
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006145

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