Methanol → Methyl 3-bromo-6-(phenylthio)-benzoate
반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:18]O>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([S:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:9][CH:10]=1)[C:5]([O:7][CH3:18])=[O:6]참가 물질
4
실험 절차
478 g of 3-bromo-6-(phenylthio)-benzoic acid in 1.5 litres of methanol and 200 ml of concentrated sulphuric acid are heated under reflux for 8 hours. The solution is concentrated under reduced pressure, treated with water and extracted with water. The organic solution is washed with aqueous sodium bicarbonate solution, dried over magnesium sulphate and concentrated under reduced pressure. There is obtained methyl 3-bromo-6-(phenylthio)-benzoate as a yellow oil.
후처리
- temperatureunder reflux for 8 hours
- concentrationThe solution is concentrated under reduced pressure
- additiontreated with water
- extractionextracted with water
- washThe organic solution is washed with aqueous sodium bicarbonate solution
- dry with materialdried over magnesium sulphate
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-ca0f3d8f232543b5b12f4da66edcf61d
- 출처 데이터셋
- uspto-grants-1977_02
- 특허 번호
- US04006145
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