2-(Cyclohexylthio)-1H-isoindole-1,3(2H)-dione → Phthalimide

HRID 435729

반응식

HRID 435729 반응식
C1(S[N:8]2[C:12](=[O:13])[C:11]3=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]3[C:9]2=[O:18])CCCCC1>CCCCCCC>[C:12]1(=[O:13])[NH:8][C:9](=[O:18])[C:10]2=[CH:17][CH:16]=[CH:15][CH:14]=[C:11]12

참가 물질

3

반응물 1

HCID 287772-(Cyclohexylthio)-1H-isoindole-1,3(2H)-dione

생성물 1

HCID 6809Phthalimide

시약·촉매·용매 1

HCID 8900Heptane용매

실험 절차

13.1 Grams (0.05 mole) of N-(cyclohexylthio)phthalimide and 6.9 grams (0.05 mole) of benzoyl thiol(thiobenzoic acid) in 150 ml of heptane are stirred overnight at room temperature. The precipitate is recovered by filtration, washed with carbon tetrachloride and dried. 7.3 Grams of phthalimide (m.p. 234° C) are obtained. The solvent is removed from the filtrate by evaporation under reduced pressure. 12 Grams (95% yield) of product, a light brown liquid, are obtained. The identity of the benzoylcyclohexyl disulfide is confirmed by GLC and NMR analyses. Analysis gives 25.51% sulfur compared to 25.45% sulfur calculated for C13H16OS2. Similarly, except N-(2-benzothiazolylthio)phthalimide is one reactant, there is obtained benzoyl-2-benzothiazolyl disulfide.

후처리

  1. filtrationThe precipitate is recovered by filtration
  2. washwashed with carbon tetrachloride
  3. customdried

출처 및 근거

ORD 기록
ord-1f3f968f02cf4a27bffac25feb1237a1
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006155

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