Water → 2-Azido-1-oxo-1lambda~5~-quinoline

HRID 435740노트

반응식

HRID 435740 반응식
Cl.Cl[C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[O-:13].[N-:14]=[N+:15]=[N-:16].[Na+].O>CC(C)=O>[N:14]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[O-:13])=[N+:15]=[N-:16]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 21481204136545-12-5

생성물 1

HCID 126998242-Azido-1-oxo-1lambda~5~-quinoline

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

In this example, 2.00 grams (0.009 mol) of 2-chloroquinoline N-oxide hydrochloride and 2.00 grams (0.031 mol) of sodium azide were added to and dissolved in 50 ml. of water and 100 ml. of acetone and the resulting solution stirred for 72 hours at 25° C. A solid separated and was collected by filtration. Recrystallization of this solid from benzene gave 2-azidoquinoline N-oxide in a yield of 1.01 grams or 58% of theory having a melting point of 103.5° C. to 104.5° C. with decomposition.

후처리

  1. dissolutiondissolved in 50 ml
  2. customA solid separated
  3. filtrationwas collected by filtration
  4. customRecrystallization of this solid from benzene

출처 및 근거

ORD 기록
ord-d2329f2964394517995e3d7e4c5df4d0
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006160

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