Formaldehyde → 2-(hydroxymethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

HRID 435811

반응식

HRID 435811 반응식
[CH:1]1[CH:2]=[C:3]2[C:8]3=[C:9]([C:11]([NH:13][C:14](=[O:15])[C:7]3=[CH:6][CH:5]=[CH:4]2)=[O:12])[CH:10]=1.[CH2:16]=[O:17]>CN(C)C=O>[OH:17][CH2:16][N:13]1[C:14](=[O:15])[C:7]2[CH:6]=[CH:5][CH:4]=[C:3]3[C:8]=2[C:9](=[CH:10][CH:1]=[CH:2]3)[C:11]1=[O:12]

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 66491Naphthalimide

생성물 1

HCID 114135142-(hydroxymethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

30 g. (0.15 mole) of 1,8-naphthalimide and 12.5 ml. of 37% aqueous formaldehyde (0.17 mole) are combined in 100 ml. of dimethylformamide and heated on a hot plate (90°-110°) until all the materials dissolve. The solution is then allowed to stand overnight at 25°. The resulting precipitate is filtered off, washed with water and recrystallized from dioxane. This material is dried overnight at 25° (0.1 mm.) to yield 26.4 g. of the titled compound which has an indistinct melting point.

후처리

  1. dissolutiondissolve
  2. filtrationThe resulting precipitate is filtered off
  3. washwashed with water
  4. customrecrystallized from dioxane
  5. customThis material is dried overnight at 25° (0.1 mm.)
  6. customto yield 26.4 g

출처 및 근거

ORD 기록
ord-3eab9337358e44f183a0432cc8c51e09
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006238

연결된 노트

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