Diisopropyl Ether → 2-Ethylamino-5H-s-triazolo[5,1-a]isoindole

HRID 436196노트

반응식

HRID 436196 반응식
[C:1]([NH:4][C:5]1[N:16]=[C:8]2[C:9]3[C:14]([CH2:15][N:7]2[N:6]=1)=[CH:13][CH:12]=[CH:11][CH:10]=3)(=O)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OC(C)C)(C)C>C(COC)OC>[CH2:1]([NH:4][C:5]1[N:16]=[C:8]2[C:9]3[C:14]([CH2:15][N:7]2[N:6]=1)=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH3:2]

참가 물질

5

반응물 3

HCID 7914Diisopropyl EtherHCID 21226445Aluminium lithium hydrideHCID 214552742-Acetamido-5H-s-triazolo[5,1-a]isoindole

생성물 1

HCID 214552822-Ethylamino-5H-s-triazolo[5,1-a]isoindole수율 60%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

2-Acetamido-5H-s-triazolo[5,1-a]isoindole is reduced with lithium aluminum hydride at 0-10°C in dimethoxyethane. Yield 60%. M.p. 150-2°C (isopropyl ether).

출처 및 근거

ORD 기록
ord-1698e8343a5d4194b67064ab35228daa
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04007276

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