Dichloromethane → HCID 21455283, 화합물

HRID 436198노트

반응식

HRID 436198 반응식
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:26]=[C:18]3[C:19]4[C:24]([CH2:25][N:17]3[N:16]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.C(Cl)Cl>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[N:26]=[C:18]3[C:19]4[C:24]([CH2:25][N:17]3[N:16]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:12]=[CH:13][CH:14]=1

참가 물질

5

반응물 2

HCID 6344DichloromethaneHCID 21455293HCID 21455293, 화합물

생성물 1

HCID 21455283HCID 21455283, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

2-(3-Benzyloxyphenyl)-5H-s-triazolo[5,1-a] isoindole (17 g) is suspended in 500 ml of ethanol and hydrogenated at atmospheric pressure and room temperature in the presence of 3 g of 10% Pd on charcoal. After addition of 500 ml of methylene chloride, the catalyst is filtered off and the solution is concentrated to dryness. The title product is purified by crystallization from dioxane. Yield 10.68 g (85.7%); m.p. 251-2°C.

후처리

  1. filtrationthe catalyst is filtered off
  2. concentrationthe solution is concentrated to dryness
  3. customThe title product is purified by crystallization from dioxane

출처 및 근거

ORD 기록
ord-9a82c6f61a1e4f68bfca44da947ee874
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04007276

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