Potassium Cyanide → HCID 178510898, 화합물

HRID 436210

반응식

HRID 436210 반응식
Cl[CH2:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[NH:5][N:4]=1.[C-:13]#[N:14].[K+]>C(O)C.O>[C:13]([CH2:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[NH:5][N:4]=1)#[N:14]

참가 물질

5

반응물 2

HCID 9032Potassium CyanideHCID 178478451HCID 178478451, 화합물

생성물 1

HCID 178510898HCID 178510898, 화합물수율 69.9%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
5 °C

실험 절차

A solution of 3-chloromethyl-5-chloro-1H-indazole (4.5 g) in ethanol (50 ml) is dropwise added to a solution of potassium cyanide (17 g) in water (10 ml) while stirring at 5° C, and the resulting mixture is stirred at room temperature for 2 hours and at 50° C for 2 hours. The reaction mixture is cooled and the precipitated potassium chloride is removed by filtration. The filtrate is concentrated under reduced pressure, admixed with water and extracted with ether. The ether layer is washed with water, dried over anhydrous magnesium sulfate and concentrated to give 3-cyanomethyl-5-chloro-1H-indazole (3.0 g) as resinous material.

후처리

  1. stirringthe resulting mixture is stirred at room temperature for 2 hours and at 50° C for 2 hours
  2. temperatureThe reaction mixture is cooled
  3. customthe precipitated potassium chloride is removed by filtration
  4. concentrationThe filtrate is concentrated under reduced pressure
  5. extractionextracted with ether
  6. washThe ether layer is washed with water
  7. dry with materialdried over anhydrous magnesium sulfate
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b592167866d14dcd8943918814b4694a
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04008070

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