참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Nitrophenyl trifluoroacetate | HCID 69569 | — |
| 반응물 | 1,2,3,4-Tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid | HCID 90301 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | HCID 178524481 | HCID 178524481 | 65.3% |
반응 단계
Uracil-5-carboxylic acid (1.0 g) is dissolved in dry pyridine (20 ml) under heating. p-Nitrophenyl trifluroacetate (1.8 g) is added to the solution which is subsequently stirred at 45° C for 30 minutes. Then, the solution is concentrated to dryness under reduced pressure, and the cyrstals thus obtained are washed with chloroform and then acetone to give the active ester, i.e. p-nitrophenyl 2,4-dihydroxypyrimidine-5-carboxylate (1.16 g). M.P. 298°-299° C (decomp.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04008220 |
|---|
| 출처 데이터셋 | uspto-grants-1977_02 |
|---|
| ORD ID | ord-973d09fdd4f848038325b3f993b5ec89 |
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| 출처 메모 | uspto-grants-1977_02 |
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