Formaldehyde → N-(Hydroxymethyl)-2-(thiophen-2-yl)acetamide

반응식

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH2:9])=[O:8].C=O.[C:12](=O)([O-])[O-:13].[K+].[K+]>>[OH:13][CH2:12][NH:9][C:7](=[O:8])[CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 712Formaldehyde

HCID 11430Potassium Carbonate

HCID 78208Thiophen-2-acetamide

생성물 1

HCID 21452354N-(Hydroxymethyl)-2-(thiophen-2-yl)acetamide

반응 조건

온도: 0 °C

실험 절차

A mixture of 2-thienylacetamide, formaldehyde solution (37%, 1 equivalent) and a catalytic amount of potassium carbonate is warmed on a steam bath until a homogeneous solution is obtained. The solution is cooled to 0° C. overnight and the resulting solid collected by filtration.