참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Hydrazine | HCID 9321 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 3,4-Dihydro-isoquinolin-1-ylamine | HCID 9793824 | — |
| 반응물 | 1-Ethoxy-3,4-dihydroisoquinoline | HCID 12349038 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-Hydrazinyl-3,4-dihydroisoquinoline | HCID 12349041 | — |
반응 단계
A mixture of 1-amino-3,4-dihydroisoquinoline (VI: R=R'=Y=Y'=Z=Z'=H) hydrochloride (m.p. 133°-134° C., 0.5 g.), prepared from 1-ethoxy-3,4-dihydroisoquinoline and ammonium chloride, sodium carbonate (0.38 g.), hydrazine (0.41 g.) and ethanol (15 ml.) was stirred (at 25° C.). The mixture was filtered. An ether solution of the crystals which separated from the filtrate on chilling was washed with water, dried and filtered. Concentration of the filtrate and crystallization of the residue from ether afforded 1-hydrazino-3,4-dihydroisoquinoline (0.44 g.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04009170 |
|---|
| 출처 데이터셋 | uspto-grants-1977_02 |
|---|
| ORD ID | ord-c56f3b2b50184e3084ea8ec85fc05f53 |
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| 출처 메모 | uspto-grants-1977_02 |
|---|
