2,3-Dihydroxybutanedioic Acid → 3-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide tartrate

HRID 436486노트

반응식

HRID 436486 반응식
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]([C:12](=[S:14])[NH2:13])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1.[C:15]([OH:24])(=[O:23])[CH:16]([CH:18]([C:20]([OH:22])=[O:21])[OH:19])[OH:17]>C(O)(C)C>[C:20]([CH:18]([CH:16]([C:15]([OH:24])=[O:23])[OH:17])[OH:19])([OH:22])=[O:21].[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]([C:12](=[S:14])[NH2:13])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 30039215,6,7,8-Tetrahydro-3-methyl-8-quinolinecarbothioamide

생성물 1

HCID 203583983-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide tartrate

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

To a solution of 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide (13 g.) in hot isopropylalcohol (130 ml.) was added a solution of 9.5 g. tartaric acid in hot isopropylalcohol (65 ml.). The solution was filtered and allowed to cool. The precipitated crystals of the tartrate were removed by filtration, washed with a little cold isopropyl alcohol and dried. Yield 10.2 g, 158°-160° C, Found: C, 50.56% H, 5.67%; N, 7.90%. Calc. for C15H20N2O6S : C, 50.55%; H, 5.65%; N, 7.86%.

후처리

  1. filtrationThe solution was filtered
  2. temperatureto cool
  3. customThe precipitated crystals of the tartrate were removed by filtration
  4. washwashed with a little cold isopropyl alcohol
  5. customdried
  6. customYield 10.2 g, 158°-160° C, Found

출처 및 근거

ORD 기록
ord-41834096b23748b5942fb4b706306988
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04009169

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