Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 8-fluoro-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Dimethylhydroxylamine | HCID 27970 | — |
| 반응물 | 8-fluoro-1-(bromomethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 23337462 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 8-fluoro-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 23463946 | — |
반응 단계
In the manner given in Example 16, a solution of N,N-dimethylhydroxylamine in dimethylformamide is treated with sodium hydride suspended in mineral oil, and the mixture is treated with 8-fluoro-1-(bromomethyl)-6-phenyl-4H-s-triazolo [4,3-a][1,4]benzodiazepine to give 8-fluoro-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine, N1 -oxide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04009175 |
| 출처 데이터셋 | uspto-grants-1977_02 |
| ORD ID | ord-d317f431a93c4497a9a5f6dc9de4b9b8 |
| 출처 메모 | uspto-grants-1977_02 |