Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 2-(4,4-Diethoxybutyl)isoindoline-1,3-dione | HCID 12805186 | — |
| 용매 | 4,4-Diethoxybutylamine | HCID 80672 | — |
| 생성물 | 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal | HCID 77150 | — |
반응 단계
Protect the amino function in 4,4-diethoxybutylamine by conversion thereof to a phthalimido function. Hydrolyze the resultant 1-phthalimido-4,4-diethoxybutane with 1N aqueous sulfuric acid at 25° C to obtain 4-phthalimidobutanal. Subject the compound to reductive amination using ammonium chloride and sodium cyanoborohydride in aqueous methanol at 25° C to obtain 4-phthalimidobutylamine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04009328 |
| 출처 데이터셋 | uspto-grants-1977_02 |
| ORD ID | ord-3a306dee696a447e8932b041cbcf69d2 |
| 출처 메모 | uspto-grants-1977_02 |