Potassium Hydroxide → N-{8-[(1,3-benzodioxol-5-ylcarbonyl)amino]octyl}-1,3-benzodioxole-5-carboxamide

HRID 436639

반응식

HRID 436639 반응식
[CH2:1]1[O:12][C:11]2[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=2[O:2]1.[CH2:13]([NH2:22])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21].[OH-:23].[K+]>C(Cl)CCl>[CH2:1]1[O:12][C:11]2[CH:10]=[CH:9][C:5]([C:6]([NH:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][NH:22][C:6](=[O:7])[C:5]3[CH:9]=[CH:10][C:11]4[O:23][CH2:1][O:2][C:3]=4[CH:4]=3)=[O:7])=[CH:4][C:3]=2[O:2]1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 242501,8-OctanediamineHCID 27347491,3-Benzodioxole-5-carbonyl chloride

생성물 1

HCID 3542149N-{8-[(1,3-benzodioxol-5-ylcarbonyl)amino]octyl}-1,3-benzodioxole-5-carboxamide

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

m.p. 179°-180° C., 21.6 g., was prepared as in Example 1 using 3,4-methylenedioxybenzoyl chloride (from 30 g. of 3,4-methylenedioxybenzoic acid as in Example 6) in 100 ml. of ethylene dichloride, 11.5 g. of 1,8-octanediamine, 200 ml. of 10% aqueous potassium hydroxide solution, 500 ml. of ethylene dichloride and recrystallization from ethanol.

후처리

  1. customof ethylene dichloride and recrystallization from ethanol

출처 및 근거

ORD 기록
ord-ba41fc3b76a24b8986fac562f02932ee
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04009208

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