Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → Potassium Hydroxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Bromocyclobutane | HCID 78110 | — |
| 반응물 | 4-Cyclopropoxybenzoic acid | HCID 21452864 | — |
| 반응물 | Ethyl 4-cyclobutyloxybenzoate | HCID 21452944 | — |
| 반응물 | 2-Ethyl-4-hydroxybenzamide | HCID 21453012 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Potassium Hydroxide | HCID 14797 | 10% |
| 생성물 | 4-Cyclobutoxybenzoic acid | HCID 21452881 | — |
반응 단계
The intermediate 4-cyclobutyloxybenzoic acid was prepared following the procedure described in Example 108 for the preparation of the corresponding 4 -cyclopropyloxybenzoic acid using 25 g. of ethyl 4-hydroxybenzamide, 23.1 g. of cyclobutyl bromide, 31 g. of anhydrous potassium carbonate, 2.5 g. of potassium iodide and 300 ml. of dimethylformamide to yield 20.1 g. of ethyl 4-cyclobutyloxybenzoate, which was then hydrolyzed by heating with 200 ml. of 10% aqueous potassium hydroxide solution as in Example 108 to yield 12.7 g. of 4-cyclobutyloxybenzoic acid, m.p. 192°-195° C. after recrystallization from 400 ml. of acetonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04009208 |
| 출처 데이터셋 | uspto-grants-1977_02 |
| ORD ID | ord-412f674b2e844eccb0a5302d1e76cbd2 |
| 출처 메모 | uspto-grants-1977_02 |