Chloride → N-[3-(propionylamino)phenyl]cyclopropanecarboxamide

HRID 436681

반응식

HRID 436681 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[NH:5][C:6](=[O:9])[CH2:7][CH3:8].C([O-])(=O)C.[Na+].[CH:18]1([C:21](Cl)=[O:22])[CH2:20][CH2:19]1.[Cl-]>C(O)(=O)C>[C:6]([NH:5][C:4]1[CH:3]=[C:2]([CH:12]=[CH:11][CH:10]=1)[NH:1][C:21]([CH:18]1[CH2:20][CH2:19]1)=[O:22])(=[O:9])[CH2:7][CH3:8]

참가 물질

6

반응물 4

HCID 312ChlorideHCID 77637Cyclopropanecarbonyl chlorideHCID 89953N-(3-Aminophenyl)propanamideHCID 517045Sodium Acetate

생성물 1

HCID 17188249N-[3-(propionylamino)phenyl]cyclopropanecarboxamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Meta-aminopropionanilide, 13.1 g. (0.08 mole) is dissolved in 200 ml. of a 50/50 v/v mixture of glacial acetic acid and saturated sodium acetate solution. To this solution is added 9.2 g. (0.088 moles) of cyclopropane carbonyl chloride. The chloride is added slowly with adequate stirring and cooling. The product, which crystallizes from the solution, is collected by filtration. The product is consecutively washed with a 5 percent solution of sodium hydroxide, a 5 percent solution of hydrochloric acid and water. After washing, the crystals are dried. There is obtained 15 g. (81 percent of theory) of the title compound, m.p. 185°-186° C.

후처리

  1. dissolution(0.08 mole) is dissolved in 200 ml
  2. additionTo this solution is added 9.2 g
  3. temperaturecooling
  4. customThe product, which crystallizes from the solution
  5. filtrationis collected by filtration
  6. washThe product is consecutively washed with a 5 percent solution of sodium hydroxide
  7. washAfter washing
  8. customthe crystals are dried
  9. customThere is obtained 15 g

출처 및 근거

ORD 기록
ord-4f74be1ed0ec4c47b00028e01f828779
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028093

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