Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Chloro-3-fluoro-propan-2-one → 7-chloro-2-[[2-chloro-1-(fluoromethyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Chloro-3-fluoro-propan-2-one | HCID 228396 | — |
| 반응물 | 7-Chloro-5-(2-chlorophenyl)-2-hydrazinyl-3H-1,4-benzodiazepine | HCID 12390875 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 7-chloro-2-[[2-chloro-1-(fluoromethyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine | HCID 54416851 | — |
반응 단계
In the manner given in Example 1, 7-chloro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1-chloro-3-fluoropropanone under nitrogen to give 7-chloro-2-[[2-chloro-1-(fluoromethyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04028356 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-4c30f50382404e4a8ee6786b0e344893 |
| 출처 메모 | uspto-grants-1977_06 |