Benzene, 1-isocyanato-4-nitro- → 6-Methyl-2[3-(p-nitrophenyl)ureido]-4-thiocyanatobenzothiazole

HRID 436815

반응식

HRID 436815 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([S:12][C:13]#[N:14])[C:5]=2[N:6]=1.[N+:15]([C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1)([O-:17])=[O:16]>CN(C)C=O>[CH3:11][C:9]1[CH:8]=[C:7]([S:12][C:13]#[N:14])[C:5]2[N:6]=[C:2]([NH:1][C:25]([NH:24][C:21]3[CH:20]=[CH:19][C:18]([N+:15]([O-:17])=[O:16])=[CH:23][CH:22]=3)=[O:26])[S:3][C:4]=2[CH:10]=1

참가 물질

4

반응물 2

HCID 66012Benzene, 1-isocyanato-4-nitro-HCID 124057302-Amino-6-methyl-4-thiocyanatobenzothiazole

생성물 1

HCID 124057346-Methyl-2[3-(p-nitrophenyl)ureido]-4-thiocyanatobenzothiazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2-amino-6-methyl-4-thiocyanatobenzothiazole (35 g., 0.16 mole) in dimethylformamide (250ml.) was treated slowly with p-nitrophenyl isocyanate (27 g., 0.16 mole). The reaction was then heated under stirring on the steam bath for 5 hours. The mixture was then filtered hot. The solution was chilled in an ice bath and filtered. The product was combined with the solid initially filtered to give 40 g. (65%) of off-white solid.

후처리

  1. temperatureThe reaction was then heated
  2. filtrationThe mixture was then filtered hot
  3. temperatureThe solution was chilled in an ice bath
  4. filtrationfiltered
  5. filtrationinitially filtered
  6. customto give 40 g

출처 및 근거

ORD 기록
ord-dad3e3216145481aac5d60dfbaffdb3f
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028374

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