3-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl ester → thieno[3,4-d]isothiazol-3(2H)-one 1,1-dioxide

HRID 436829노트

반응식

HRID 436829 반응식
[S:1]([C:5]1[C:6]([C:10]([O:12]C)=O)=[CH:7][S:8][CH:9]=1)(=[O:4])(=[O:3])[NH2:2]>C[O-].[Na+]>[O:12]=[C:10]1[C:6]2=[CH:7][S:8][CH:9]=[C:5]2[S:1](=[O:4])(=[O:3])[NH:2]1

참가 물질

3

반응물 1

HCID 30422843-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl ester

생성물 1

HCID 12593672thieno[3,4-d]isothiazol-3(2H)-one 1,1-dioxide

시약·촉매·용매 1

HCID 10942334Sodium Methoxide용매

실험 절차

31.6 g (0.143 mole) of methyl 4-sulfamoylthiophene-3-carboxylate (IX; R1 =H; R=CH3) is refluxed for 20 hours in 150 ml of 1N methanolic sodium methylate solution. The methanol is evaporated, the residue taken up in water, and the aqueous phase extracted with methylene chloride and acidified with concentrated hydrochloric acid; the product precipitates as crystals. It may be recrystallized from water or ethanol.

후처리

  1. customThe methanol is evaporated
  2. extractionthe aqueous phase extracted with methylene chloride
  3. customthe product precipitates as crystals
  4. customIt may be recrystallized from water or ethanol

출처 및 근거

ORD 기록
ord-b62206d4007544b999d978bdea214581
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028373

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