Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate → 2H,3H-1lambda6-thieno[2,3-d][1,2]thiazole-1,1,3-trione

HRID 436832

반응식

HRID 436832 반응식
[S:1]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12]C)=O)(=[O:4])(=[O:3])[NH2:2]>C[O-].[Na+]>[O:12]=[C:10]1[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[S:1](=[O:4])(=[O:3])[NH:2]1

참가 물질

3

반응물 1

HCID 101012Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate

생성물 1

HCID 140865502H,3H-1lambda6-thieno[2,3-d][1,2]thiazole-1,1,3-trione

시약·촉매·용매 1

HCID 10942334Sodium Methoxide용매

실험 절차

32 g (0.145 mole) of methyl 3-sulfamoylthiophene-2-carboxylate (IX) in 145 ml of 1N methanolic sodium methylate solution is refluxed for 18 hours. The methanol is then evaporated off, the residue is taken up in water and a small amount of sodium bicarbonate, and the aqueous phase is extracted with methylene chloride and acidified with concentrated hydrochloric acid, whereupon the product precipitates as crystals which can be reprecipitated from water or ethanol.

후처리

  1. customThe methanol is then evaporated off
  2. extractiona small amount of sodium bicarbonate, and the aqueous phase is extracted with methylene chloride
  3. customprecipitates as crystals which
  4. customcan be reprecipitated from water or ethanol

출처 및 근거

ORD 기록
ord-a1ab9e7cc2c4413ba4fb6912a1c95fbe
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028373

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