Diethylamine → N,N-diethyl-7,11-dimethyl-3-oxo-6,10-dodecadienamide

HRID 436876노트

반응식

HRID 436876 반응식
[CH3:1][C:2]([CH2:13][CH2:14][CH:15]=[C:16]([CH3:18])[CH3:17])=[CH:3][CH2:4][CH2:5][C:6](=[O:12])[CH2:7][C:8]([O:10]C)=O.[CH2:19]([NH:21][CH2:22][CH3:23])[CH3:20]>>[CH2:19]([N:21]([CH2:22][CH3:23])[C:8](=[O:10])[CH2:7][C:6](=[O:12])[CH2:5][CH2:4][CH:3]=[C:2]([CH3:1])[CH2:13][CH2:14][CH:15]=[C:16]([CH3:18])[CH3:17])[CH3:20]

참가 물질

3

반응물 2

HCID 8021DiethylamineHCID 53708905Methyl 3-oxo-7,11-dimethyl-dodeca-6,10-dienoate

생성물 1

HCID 53763853N,N-diethyl-7,11-dimethyl-3-oxo-6,10-dodecadienamide

실험 절차

5.4 g of the product of Example 3 and 10.8ml of diethylamine were stirred in a closed auto clave at 110° C. for 70 hours and after cooling, the reaction mixture was recovered and evaporated under reduced pressure. The residue was chromatographed over silica and was eluted with a 1-1 ethyl etherpetroleum ether (b.p.= 40°-75° C.) mixture to obtain 3.6 g of N,N-diethyl-7,11-dimethyl-3-oxo-6,10-dodecadienamide in the form of an orange oil.

후처리

  1. temperatureafter cooling
  2. customthe reaction mixture was recovered
  3. customevaporated under reduced pressure
  4. customThe residue was chromatographed over silica
  5. washwas eluted with a 1-1 ethyl etherpetroleum ether (b.p.= 40°-75° C.) mixture

출처 및 근거

ORD 기록
ord-ff084c6493d74762ba4e62702df6086c
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028386

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