Methanol → Methyl 11-methoxy-7,11-dimethyl-3-oxo-6-dodecenoate

HRID 436880노트

반응식

HRID 436880 반응식
S(=O)(=O)(O)O.[CH3:6][C:7]([CH2:18][CH2:19][CH:20]=[C:21]([CH3:23])[CH3:22])=[CH:8][CH2:9][CH2:10][C:11](=[O:17])[CH2:12][C:13]([O:15][CH3:16])=[O:14].[CH3:24][OH:25]>O>[CH3:24][O:25][C:21]([CH3:23])([CH3:22])[CH2:20][CH2:19][CH2:18][C:7]([CH3:6])=[CH:8][CH2:9][CH2:10][C:11](=[O:17])[CH2:12][C:13]([O:15][CH3:16])=[O:14]

참가 물질

5

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 53708905Methyl 3-oxo-7,11-dimethyl-dodeca-6,10-dienoate

생성물 1

HCID 54124623Methyl 11-methoxy-7,11-dimethyl-3-oxo-6-dodecenoate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The product can be obtained in the form of a mixture of E and Z isomers by adding dropwise 3 ml of concentrated sulfuric acid to a solution of 7.6 g of the product of Example 3 in 45 ml of methanol and stirring the mixture at room temperature for 40 hours. The mixture was diluted with water and extracted with methylene chloride. The extracts were washed with water, dried over sodium sulfate and evaporated to dryness and the residue was chromatographed over silica and was eluted with a 9-1 benzene-ethyl acetate mixture to obtain 1.3 g of methyl 11-methoxy-7,11-dimethyl-3-oxo-6-dodecenoate in the form of a colorless oil.

후처리

  1. customThe product can be obtained in the form of a mixture of E and Z isomers
  2. extractionextracted with methylene chloride
  3. washThe extracts were washed with water
  4. dry with materialdried over sodium sulfate
  5. customevaporated to dryness
  6. customthe residue was chromatographed over silica
  7. washwas eluted with a 9-1 benzene-ethyl acetate mixture

출처 및 근거

ORD 기록
ord-d35d695c5bf94e7da610d4125c65cffd
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028386

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