N-Methylethylamine → 3-(N-methyl-N-ethylamino)-1,1-diphenyl-propan-2-ol

HRID 436942노트

반응식

HRID 436942 반응식
[CH3:1][NH:2][CH2:3][CH3:4].[C:5]1([CH:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:12]([OH:15])[CH2:13]Br)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(O)C>[CH3:1][N:2]([CH2:13][CH:12]([OH:15])[CH:11]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 12219N-MethylethylamineHCID 125490671,1-Diphenyl-3-bromopropan-2-ol

생성물 1

HCID 125490683-(N-methyl-N-ethylamino)-1,1-diphenyl-propan-2-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Excess N methyl-N-ethylamine was added to a solution of 1,1 -diphenyl-3-bromo-propan-2-ol (2 g.) in ethanol. After 60 hours the solution was evaporated and the residue was evaporated and the residue dissolved in dilute hydrochloric acid and ether. Basification of the acid extract and subsequent isolation through ether in the usual manner gave 3-(N-methyl-N-ethylamino)-1,1 -diphenyl-propan-2-ol isolated as the hydrochloride (1 25 g., 60%), m.p. 159° - 161°.

후처리

  1. customAfter 60 hours the solution was evaporated
  2. customthe residue was evaporated
  3. dissolutionthe residue dissolved in dilute hydrochloric acid
  4. extractionBasification of the acid extract

출처 및 근거

ORD 기록
ord-dca66422e497478faf6ec7f2f1bf388b
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028415

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