Dimethylamine → 3-Dimethylamino-1,1-diphenyl-propan-2-ol

HRID 436945노트

반응식

HRID 436945 반응식
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]([OH:11])[CH2:9]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][NH:19][CH3:20]>C(O)C>[CH3:18][N:19]([CH3:20])[CH2:9][CH:8]([OH:11])[CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 125490671,1-Diphenyl-3-bromopropan-2-ol

생성물 1

HCID 125491223-Dimethylamino-1,1-diphenyl-propan-2-ol수율 75%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1,1-Diphenyl-3-bromopropan-2-ol (500 mg.) prepared as described in Example 20 was treated with excess dimethylamine in ethanol and the solution allowed to stand overnight. Solvent was removed by evaporation and the residue dissolved in dilute hydrochloric acid and ether. Basification of the acid extract and isolation through ether in the usual manner gave 3-dimethylamino-1,1-diphenyl-propan-2-ol (330 mg., 75%), m.p. 72° - 73°.

후처리

  1. customSolvent was removed by evaporation
  2. dissolutionthe residue dissolved in dilute hydrochloric acid
  3. extractionBasification of the acid extract

출처 및 근거

ORD 기록
ord-1dfed4f348254ebc9e20da6f22ffbfc0
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028415

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