Benzyl 2-amino-2-methylpropanoate → Glycyl-alpha-aminoisobutyric acid benzyl ester hydrochloride

반응식

[CH2:1]([O:8][C:9](=[O:14])[C:10]([NH2:13])([CH3:12])[CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:15].C([O:23][C:24](=O)[C@H:25](C)[NH:26]C(=O)CN)C1C=CC=CC=1>>[ClH:15].[CH2:1]([O:8][C:9](=[O:14])[C:10]([NH2:13])([CH3:11])[CH2:12][C:24](=[O:23])[CH2:25][NH2:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 11116894Benzyl 2-amino-2-methylpropanoate

HCID 53328828Benzyl glycyl-L-alaninate hydrochloride

생성물 1

HCID 131710813Glycyl-alpha-aminoisobutyric acid benzyl ester hydrochloride

실험 절차

substitution of an equivalent amount of α-aminoisobutyric acid benzyl ester for the L-alanine benzyl ester of Example 3, and substantial repetition of the procedure detailed therein, affords glycyl-α-aminoisobutyric acid benzyl ester hydrochloride.

출처 및 근거

ORD 기록: ord-24f0480a8e4d4c39b3420989f1915ec2
출처 데이터셋: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04028319

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