2,3-Dihydroxybutanedioic Acid → 3-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide tartrate

HRID 437085노트

반응식

HRID 437085 반응식
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]([C:12](=[S:14])[NH2:13])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1.[C:15]([OH:24])(=[O:23])[CH:16]([CH:18]([C:20]([OH:22])=[O:21])[OH:19])[OH:17]>C(O)(C)C>[C:20]([CH:18]([CH:16]([C:15]([OH:24])=[O:23])[OH:17])[OH:19])([OH:22])=[O:21].[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]([C:12](=[S:14])[NH2:13])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 30039215,6,7,8-Tetrahydro-3-methyl-8-quinolinecarbothioamide

생성물 1

HCID 203583983-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide tartrate

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

To a solution of 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide (13 g.) in hot isopropyl alcohol (130ml.) was added a solution of 9.5 g. tartaric acid in hot isopropyl alcohol (65 ml.). The solution was filtered and allowed to cool. The precipitated crystals of the tartrate were removed by filtration, washed with a little cold isopropyl alcohol and dried. Yield 10.2 g, m.p. 158°-160° C., Found: C, 50.56% H, 5.67%; N, 7.90%. Calc. for C15H20N2O6S: C, 50.55% H, 5.65%; N, 7.86%.

후처리

  1. filtrationThe solution was filtered
  2. temperatureto cool
  3. customThe precipitated crystals of the tartrate were removed by filtration
  4. washwashed with a little cold isopropyl alcohol
  5. customdried

출처 및 근거

ORD 기록
ord-424b1c27aa6d442b848b5d565bfbb9ff
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04029668

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