Potassium Carbonate → 2-(Tert-butoxy)acetic acid
반응식
C(=O)([O-])[O-].[K+].[K+].[C:7]([O:11][CH2:12][C:13]([O:15]CCCC)=[O:14])([CH3:10])([CH3:9])[CH3:8]>CO.O>[C:7]([O:11][CH2:12][C:13]([OH:15])=[O:14])([CH3:10])([CH3:9])[CH3:8]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To 100 ml of a 50:50 (v/v) methanol/water solution containing 14.35 g of potassium carbonate, was added n-butyl 2-tert-butoxyacetate (6.50 g, 0.0346 mol). The mixture was heated at reflux for 17 hours and the volatiles removed on a flash evaporator. The remaining solution was cooled to approximately 0° C. and acidified to pH 3-4 with cold 50% aqueous hydrogen chloride. The product was extracted with ether, the ether extract washed with brine and dried over magnesium sulfate, then concentrated in vacuo to give the title compound as a yellow liquid.
후처리
- temperatureThe mixture was heated
- temperatureat reflux for 17 hours
- customthe volatiles removed on a flash evaporator
- extractionThe product was extracted with ether
- extractionthe ether extract
- washwashed with brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-683c16909174462faf1b49adbea715f3
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04725620
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