HCID 12353591, 화합물 → Trepibutone

HRID 437100

반응식

HRID 437100 반응식
[CH2:1]([O:3][C:4]1[CH:16]=[C:15]([O:17][CH2:18][CH3:19])[C:14]([O:20][CH2:21][CH3:22])=[CH:13][C:5]=1[C:6](/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11])=[O:7])[CH3:2]>[Pd].CO>[CH2:1]([O:3][C:4]1[CH:16]=[C:15]([O:17][CH2:18][CH3:19])[C:14]([O:20][CH2:21][CH3:22])=[CH:13][C:5]=1[C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])[CH3:2]

참가 물질

4

반응물 1

HCID 12353591HCID 12353591, 화합물

생성물 1

HCID 5536Trepibutone

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 1.0 part by weight of 3-(2',4',5'-triethoxybenzoyl)-trans-acrylic acid, 50 parts by volume of methanol and 0.2 part by weight of 5% palladium-charcoal is subjected to catalytic reduction at 25° C. under atmospheric pressure for 1 hour. After removal of the catalyst by filtration, the filtrate is evaporated and the residue is recrystallized from aqueous ethanol to give 0.85 part by weight of 3-(2',4',5'-triethoxybenzoyl)-propionic acid as pale yellow needles melting at 150°-151° C.

후처리

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. customthe filtrate is evaporated
  4. customthe residue is recrystallized from aqueous ethanol

출처 및 근거

ORD 기록
ord-76aeb5c65ee34820837e8c6b66651e38
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04029699

연결된 노트

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